Navratri 2020 Day 4: Date, colour, Kushmanda Maa Puja shubh muhurat, tithi, mantra and vidhi - Times Now
Navratri 2020 Day 4: On the Chaturthi Tithi, Shukla Paksha Ashwin, the Kushmanda form of Mother Goddess is worshipped. Read on to know the date, tithi, significance, vidhi and mantras of Kushmanda puja.
- On Chaturthi Tithi, the Kushmanda form of Maa Durga is worshipped
- She is seen mounted on a lion and is depicted with eight hands
- She represents the core of the Sun. Hence she is known as Kushmanda. Ku means (little), ushma (means warmth) and anda (means cosmic egg)
Here’s how cannabidiol may help reduce lung damage from COVID-19 - Times Now
The investigators said then more work was needed, including finding how CBD produced the significant changes as well as human trials, before it should be included as part of a treatment regimen for COVID-19.
Augusta: Researchers have found that one way Cannabidiol (CBD) appears to reduce the "cytokine storm" that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm. The study was conducted by researchers at Dental College of Georgia and Medical College of Georgia (MCG). They reported CBD's ability to improve oxygen levels and reduce inflammation as well as physical lung damage in their laboratory model of deadly adult respiratory distress syndrome, or ARDS. They showed that the apelin levels go way down with the viral infection, which has killed 1 million people worldwide, and that CBD quickly helps normalize those levels along with lung function. "It was dramatic in both directions," said Dr Babak Baban, DCG immunologist and associate dean for research, of shifting apelin levels in both circulating blood and lung tissue. Blood levels of the peptide dropped close to zero in their ARDS model and increased 20 times with CBD, they reported in the Journal of Cellular and Molecular Medicine. "CBD almost brought it back to a normal level," Dr Jack Yu, physician-scientist and chief of pediatric plastic surgery at MCG, said of the apparent first connection between CBD and apelin. Apelin is a pervasive peptide made by cells in the heart, lung, brain, fat tissue and blood, and is an important regulator in bringing both blood pressure and inflammation down, said Baban, the study's corresponding author. When our blood pressure gets high, for example, apelin levels should go up in the right place, like endothelial cells that line blood vessels, to help bring it down. Apelin should do the same to help normalize the significant increases in inflammation in the lungs and related breathing difficulties associated with ARDS. "Ideally with ARDS it would increase in areas of the lungs where it's needed to improve blood and oxygen flow to compensate and to protect," Baban said. But when they looked at their ARDS model, apelin did not do either, and instead decreased in both the lung tissue itself and the general circulation. Until they gave CBD. They reported this summer in the journal Cannabis and Cannabinoid Research that treatment with CBD reduced excessive lung inflammation, enabling improvements in lung function, healthier oxygen levels, and repair of some of the structural damage to the lungs that are classic with ARDS. The investigators said then more work was needed, including finding how CBD produced the significant changes as well as human trials, before it should be included as part of a treatment regimen for COVID-19. Now they have correlated those improvements with the regulation of apelin. While they do not attribute all CBD's benefits to apelin, they say the peptide clearly has an important role in this scenario. They also don't yet know whether the novel coronavirus, or CBD for that matter, have a direct effect on apelin, or if these are downstream consequences, but they are already pursuing answers to those unknowns. "It is an association; we don't know yet about causative, but it is a very good indicator of the disease," Baban added of the bottom line impact of the viral infection on apelin levels. The now familiar spiked virus enters human cells via the also pervasive angiotensin-converting enzyme 2, or ACE2, receptor. "The spike proteins have just the right docking mechanism," said coauthor Yu. And there is plenty of common ground between ACE2 and apelin, including the fact that many cell types and tissues have both, including the lungs. Apelin and ACE2 normally work together to control blood pressure, and upregulation of both may be helpful in cardiovascular disease, including heart failure, by decreasing blood pressure while increasing the heart's ability to pump. In fact, apelin and ACE2 work together to regulate a healthy cardiovascular system and they are factors in pretty much any condition, like obesity or hypertension, that hurt the cardiovascular system, Baban said. Like other diseases, the novel coronavirus appears to upset their positive partnership. The virus' binding to the receptor for ACE2 has been shown to decrease ACE2 levels and increase levels of the powerful blood vessel constrictor angiotensin II, because less angiotensin II gets degraded and fewer vasodilators get produced, which worsens the patient's prognosis. "Instead of ACE2 helping blood vessels relax, it helps the virus get into the host where it makes more viruses instead of helping the lungs relax and do their job," Yu added. While the researchers are still putting the pieces together, reduced levels of ACE2 appear to enable less apelin and less protection. However it happens, their finding of dramatic reductions in apelin in the face of ARDS, makes levels of the protective peptide a potential early biomarker for ARDS and response to treatment efforts, they said. The new finding was their first in learning more about how CBD produces the beneficial effects they saw in their model of ARDS. The next steps include a better understanding of the interaction between CBD, apelin and the novel coronavirus including why apelin goes down in the face of the virus and why CBD brings it up. That includes exploring how eliminating apelin affects ARDS and if CBD produces the same lung benefit without apelin. Likely the virus suppresses something that suppresses apelin, they say and CBD interferes. But they doubt the apelin-CBD interaction is the only way the compound, the second most prevalent found in the marijuana plant, works in this and other scenarios. The studies were enabled by the investigators' development of a safe, relatively inexpensive model of ARDS by giving a synthetic analog of double-stranded RNA called POLY (I:C). The novel coronavirus also has double-stranded RNA, while ours is single-stranded, so this analog produced a response similar to the virus, including the extreme lung damage that has led to the need for ventilator and other extreme support measures for patients, and is a major cause of death. Much as with the SARS-CoV-2 infection, the result is the 'cytokine storm' that reflects an over-the-top immune response in the lungs, which results in an attack rather than protection. For these studies, a control group received intranasal saline for three consecutive days while the COVID-19 model received POLY (I:C) intranasally for three days. A third group, the treatment group, received POLY ((I:C) and CBD over the same timeframe. This time they looked and also found significantly reduced apelin levels in the mice that developed COVID-like symptoms compared to controls. Treatment with CBD normalized the immune response and apelin levels, along with oxygen levels and swelling and scarring in the lungs characteristic of the deadly ARDS. "The apelinergic system is a very, very ubiquitous signaling system," Yu said. While it has diverse jobs in different places, and levels may rise and fall depending on what is needed, its levels are consistently measurable in the lungs, one of the reasons it should be a good biomarker, and it's also generally considered protective, they said. Apelin's important, diverse roles include helping ensure the placenta is well supplied with blood and the oxygen and nutrients it carries during a pregnancy. In fact, DCG and MCG investigators decided to look at apelin because of the work of Dr Evila Lopes Salles, a postdoctoral fellow with Baban in the DCG Department of Oral Biology and the study's first author, who was looking at the peptide's significant impact in gestation and clear anti-inflammatory role, Baban says. Synthetic agonists that increase apelin levels exist and are showing promise in the laboratory for cardiovascular disease, including slowing the growth rate of weak points in blood vessels called aneurysms. CBD appears to be a natural apelin agonist, the researchers concluded.
Amazon sees bumper festive sales, says first 2 days were its best ever in India - Times Now
Amazon's month-long Great Indian Festival is its biggest annual sale, where it will face off with rivals such as Flipkart and JioMart.
Bengaluru: Amazon's Great Indian Festival got off to a solid start over the weekend, with the e-commerce giant stating that the first 48 hours of the sale was the biggest ever for Amazon India in terms of value and units sold. Amazon India Vice President Manish Tiwary spoke to ET NOW on the categories and regions driving demand. "The first 48 hours have been well ahead of what our expectations were- it was the biggest ever 48 hours at Amazon.in. More than 1.1 lakh sellers got orders. The orders came from 98.4% of India's pin codes. More than 5000 small and medium businesses recorded sales worth Rs 10 lakh rupees. It was the biggest 48 hours for new customer acquisition --more than 91% of new customers came from tier 2 and below towns," said Manish Tiwary who is leading Amazon's biggest sale in India after the Covid19 pandemic. Smartphones were among the categories that saw robust demand, thanks to new launches and significant discounts. "A lot of new launches happened that did very well- OnePlus 8T, Samsung M31, OnePlus Nord. We sold more iPhones on the first day than the entire festive season last year," Tiwary said. Popular categories included smartphones, large appliances, TVs and consumer electronics. Study tables, chairs and dishwashers continued to remain popular. Industry analysts say some of the key factors driving a surge in e-commerce in India include a massive online adoption by Bharat customers post-Covid, a rise of new shopping models led by video and WhatsApp and some share of physical organised retail going to online retail. "I think this particular Great Indian Festival is more of Bharat celebrating it. 65% of new Prime customers came from Tier-2 and below. 70% of sellers are coming from smaller towns. The trend of more and more customers coming from smaller towns gets stronger with every passing month", he said. Amazon's month-long Great Indian Festival is its biggest annual sale, where it will face off with rivals such as Flipkart and JioMart. E-commerce companies are likely to see a 50% jump in gross sales to reach $4 Billion this Diwali. Market Research firm RedSeer expects the entire festive month to clock gross sales of $7 Billion in 2020, a jump of 75% compared to a year ago.
Hope of COVID-19 vaccine deployment in UK by New Year: Report - Times Now
All COVID-19 vaccines must undergo three stages of clinical trials and be assessed for safety and effectiveness by the regulator before they are given to patients
London: One of the UK's senior-most medical chiefs has indicated that a vaccine against COVID-19 could be ready to be deployed by the start of the New Year, according to a media report on Sunday. Jonathan Van-Tam, England's Deputy Chief Medical Officer and one of the government's advisers on the coronavirus pandemic, has reportedly told members of Parliament (MPs) that the vaccine created at Oxford University and being manufactured by AstraZeneca could be ready for rollout soon after Christmas in December. In India, the vaccine has a Serum Institute of India tie-up as it undergoes trials. "We aren't light years away from it. It isn't a totally unrealistic suggestion that we could deploy a vaccine soon after Christmas. That would have a significant impact on hospital admissions and deaths," The Sunday Times' quoted Van Tam as telling the MPs during a briefing last week. An MP who attended another briefing with Van-Tam told the newspaper that the medic was "very bullish about the third stage AstraZeneca results, which he expects between the end of this month and the end of next". "Van-Tam expects it to protect the elderly and vulnerable. He gave us to understand that it stopped the virus shedding' in the young. He said he would expect vaccination to start in January," the MP was quoted as saying. It comes as the UK government introduced new laws on Friday that would allow larger numbers of healthcare workers to administer flu and potential COVID-19 vaccines. "COVID-19 vaccines are being developed at speed which, if successful, will save lives," said Van-Tam, in reference to the new rules. "All vaccines must undergo three stages of clinical trials and be assessed for safety and effectiveness by the regulator before they are given to patients. The measures outlined today aim to improve access and strengthen existing safeguards protecting patients, he said. The Department of Health and Social Care (DHSC) said that the new measures would increase access to vaccines against potentially killer diseases and also support the government's plans for the roll-out of a potential COVID-19 vaccine that is proven to be safe and effective through robust clinical trials and approved for use by the regulator. "The National Health Service (NHS) has vast experience in vaccinating millions of people against diseases every year," said UK Health Secretary Matt Hancock. "These legal changes will help us in doing everything we can to make sure we are ready to roll out a safe and effective COVID-19 vaccine as soon as it has passed clinical trials and undergone rigorous checks by the regulator," he said. The aim is to increase the number of fully trained and experienced healthcare professionals to administer COVID-19 and flu vaccines under NHS and local authority occupational health schemes, as well as enable an expanded workforce that can administer these vaccinations to the public. This will make it easier and quicker for patients and healthcare workers to access the vaccines they need, protecting them against fatal diseases, the DHSC said. Therefore, if a vaccine is developed before 2021, the changes to the Human Medicine Regulations will bolster existing powers that enable the UK's Medicines and Healthcare products Regulatory Agency (MHRA) to authorise temporary supply for any treatment or vaccine needed to respond to a public health need. This means that if a vaccine has been found to meet the safety, quality and effectiveness standards by the MHRA, then vaccinations can begin without needing to wait for the European Medicines Agency who up until the end of the transition period on December 31 this year would have been the only body able to grant a licence. Dr Christian Schneider, Interim Chief Scientific Officer at the MHRA, said: "No vaccine will be deployed unless stringent standards have been met through a comprehensive clinical trial programme. "The preferred route to enable deployment of any new vaccine remains through the usual product licensing processes. But reinforced safeguards are now in place to strengthen the regulatory regime and our ability to protect public health, should temporary authorisations be necessary." The first vaccines are set to be given to the elderly and vulnerable, followed by vaccination of others most at risk. Any population-wide roll-out is expected to be a much longer-term process.
Nokia wins NASA contract to put 4G network on the moon - Times Now
The grant is part of $370 million worth of contracts signed under NASA's "Tipping Point" selections, meant to advance research and development for space exploration.
NASA has awarded Nokia of the US $14.1 million to deploy a 4G cellular network on the moon. The grant is part of $370 million worth of contracts signed under NASA's "Tipping Point" selections, meant to advance research and development for space exploration. "The system could support lunar surface communications at greater distances, increased speeds and provide more reliability than current standards," NASA noted in its contract award announcement. According to United Press International, NASA Administrator Jim Bridenstine in a live broadcast said that the space agency must quickly develop new technologies for living and working on the moon if it wants to realise its goal to have astronauts working at a lunar base by 2028. "We need power systems that can last a long time on the surface of the moon, and we need habitation capability on the surface," Bridenstine said. Nokia's research arm, Bell Labs, provided more details in a Twitter thread. The company intends for the network to support the wireless operation of lunar rovers and navigation, as well as streaming video. "Working with our partners at @Int_Machines, this groundbreaking network will be the critical communications fabric for data transmission applications, including the control of lunar rovers, real-time navigation over lunar geography and streaming of high definition video," Bell Labs said in a tweet. This is not Nokia's first attempt to launch an LTE network on the moon. It was planned to do this in 2018 in collaboration with PTScientists, a German space company, and Vodafone UK to launch an LTE network at the site of the Apollo 17 landing, but the mission never got off the ground.
Bigg Boss 14's Hina Khan, Sidharth Shukla get into nasty fight while deciding a winner between Jasmin, Nikki - Times Now
In tonight's episode of Bigg Boss 14, Hina Khan and Sidharth Shukla will be seen in loggerheads while deciding a winner between Jasmin Bhasin and Nikki Tamboli during a task.
All those who had watched Bigg Boss 14, sure can’t wait for the clock to strike 10:30 tonight! The house of Bigg Boss 14 is witnessing some massive competition brewing between them, in an attempt to permanently receive their belongings from the BB Mall. While Rubina Dilaik-Pavitra Punia, Shehzad Deol-Nishant Singh Malkhani, Eijaz Khan-Rahul Vaidya got into a tussle with one another last night, fans are looking forward to some stringent competition brewing between Jasmin Bhasin and Nikki Tamboli. For the unaware, BiggBoss, yesterday (October 15), gave the contestants a chance to get back their personal belongings if they managed to win against their opponent during a task. Out of the names mentioned above, Pavitra, Nishant and Eijaz emerged winners and got their belongings back while the others lost. However, today, the audience will get to see a never-seen avatar of Jasmin and her fight with Nikki as the duo charged against each other. The decision-makers of the task are the toofani seniors Sidharth Shukla, Hina Khan and Gauahar Khan. However, as per the promo of tonight’s video, close friends Hina and Sidharth will be seen getting into a nasty fight in an attempt to come to a conclusion and declare the winner of the task. Hina was seen shrieking at Sidharth as she said, “Mujhe mat sanchalan sikhao” (Don’t teach me how to look over a task). To this, Sidharth replies, “Main chup kyu rakhunga? Main chup rehne thodi na aaya hoon.” (Why will I keep mum? I haven’t come here to remain shut). Pat came Hina’s reply as she asks Sidharth to mind his own business. And then Sidharth was heard saying, “Jasmin meri dost hain lekin main galat decision nahin lena chahta.” (Jasmin is my friend but I don’t want to take any wrong decisions). The caption accompanied by Colors TV’s Instagram page could be read, “Freshers ke task mein, jeet par faisle mein phasey #BB14 house ke Seniors!” Check out the promo of tonight’s episode here: A while back, fans also got a glimpse of what will happen in tonight’s task between Jasmin and Nikki. From pushing one another to wreaking their baskets and constant verbal spats, Jasmin was seen opening the video with the words, “Dikha diya aapne apna personality. Gaaliyan dete ho gandi-gandi”. (You’ve shown your personality. You hurl abuses). However, what caught the audience’s fancy was the actress’ rumoured boyfriend Aly Goni’s comment on the video that could be read, “U already said that in ur first line.” Take a look: Who do you think will emerge the winner between Jasmin and Nikki? Find out at tonight’s episode!
As India seeks to tame the Chinese dragon, top Army General heads to US on crucial visit - Times Now
A military statement said the visit will enhance the collaboration between the Indian and US armies at operational as well as strategic level.
New Delhi: A top Indian Army General is all set to visit the United States of America to lay the foundation for a strengthened relationship between the armies of the two countries. Lt Gen SK Saini, Vice Chief of the Army Staff, will be in the US from October 17 to 20 with an aim to enhance military cooperation between the two armies. Crucially, the Indian Army Vice Chief will witness first-hand training and equipment capabilities of the US Army at the US Army Pacific Command. “The Vice Chief of the Army Staff will visit the US Army Pacific Command (USARPRAC), the Army component of Indo-Pacific Command (INDOPACOM), and exchange ideas extensively with the military leadership (there) apart from witnessing training and equipment capabilities of the US Army,” an official release stated on Friday. Talks will also focus on the procurement of equipment and training of personnel in niche domains. “The Vice Chief of the Army Staff, during his visit to the US, will also visit INDOPACOM where aspects of military cooperation and furthering military to military engagement including procurements, training in niche domains, joint exercises and capability building will be discussed,” the release stated. The statement asserted that the visit will enhance the collaboration between the Indian and US armies at operational as well as strategic level. “The visit will further enhance the operational and strategic level collaboration between Indian and US armies, which is emphasised by the fact that India is participating in joint exercises - Yudh Abhyas (February 2021) and Vajra Prahar (March 2021) with the US despite COVID-19 restrictions,” the statement said, highlighting that the military cooperation was going ahead despite the coronavirus pandemic related challenges. The visit assumes significance in light of the fact that India and China are engaged in an unprecedented border standoff in eastern Ladakh and months of negotiations at military and diplomatic levels have failed to lead to a breakthrough and result in disengagement. The visit also comes in light of the fact that the US has become more assertive of freedom of navigation in the South China Sea, in a direct challenge to Beijing which asserts control and ownership of much of the region. The US’ stance towards China has seen a marked shift in the recent months, especially post COVID-19 pandemic, with tensions between the two countries surging to an all-time high. Experts believe an enhanced strategic and defence cooperation between India and the US will help keep China and its moves in check, at least in the Indian Ocean and Pacific region.
People with this blood group may be less vulnerable to COVID-19 infection - Times Now
Two studies published in the journal Blood Advances suggest that individuals with blood type 'O' may be less vulnerable to Covid-19 infection.
London: New research adds to the growing body of evidence that people with blood type 'O' may have a lower risk of Covid-19 infection and reduced likelihood of severe outcomes, including organ complications if they do get sick. Two studies published in the journal Blood Advances suggest that individuals with blood type 'O' may be less vulnerable to Covid-19 infection. "It is very important to consider the proper control group because blood type prevalence may vary considerably in different ethnic groups and different countries," said study author Torben Barington from the University of Southern Denmark. "We have the advantage of a strong control group - Denmark is a small, ethnically homogenous country with a public health system and a central registry for lab data - so our control is population-based, giving our findings a strong foundation," Barington added. For the findings, the research team compared Danish health registry data from more than 473,000 individuals tested for Covid-19 to data from a control group of more than 2.2 million people from the general population. Among the Covid-19 positive, they found fewer people with blood type 'O' and more people with 'A', 'B', and 'AB' types. The study results suggest that people with blood types 'A', 'B', or 'AB' may be more likely to be infected with Covid-19 than people with type 'O'. The researchers did not find any significant difference in the rate of infection between 'A', 'B', and 'AB' types. The findings also showed that blood groups 'A' and 'AB' associated with an increased risk of severe clinical outcomes of Covid-19 infection. People with blood groups 'A' or 'AB' appear to exhibit greater Covid-19 disease severity than people with blood groups 'O' or 'B', according to a separate retrospective study. Researchers found that patients with blood groups 'A' or 'AB' were more likely to require mechanical ventilation, suggesting that they had greater rates of lung injury from Covid-19. They also found more patients with blood group 'A' and 'AB' required dialysis for kidney failure. "The unique part of our study is our focus on the severity effect of blood type on Covid-19. We observed this lung and kidney damage, and in future studies, we will want to tease out the effect of blood group and Covid-19 on other vital organs," the authors wrote. Earlier, another study published in the journal Clinical Infectious Diseases that people with blood group 'A' may be more prone to Covid-19 infection while those with blood type 'O' have a lower risk of contracting the virus.
Pakistan, China re-elected to UNHRC; US slams United Nations for electing 'authoritarian regimes' - Times Now
The United States slammed the United Nations for electing “authoritarian regimes” were elected to the UNHRC.
- Mike Pompeo slammed the United Nations for electing 'authoritarian regimes'
- China received only 139 votes compared to the 180 it received in 2016
- 'China getting less votes shows more states are disturbed by its abysmal rights record'
Delhi: 45 more COVID-19 deaths take toll to 5,854; infection tally past 3.14 lakh - Times Now
In Delhi, the tally of active cases on Tuesday rose to 21,490 from 20,535 the previous day.
New Delhi: The national capital recorded 45 COVID-19 fatalities on Tuesday, taking the death toll due to the disease to 5,854, while 3,036 fresh cases took the infection tally to over 3.14 lakh, authorities said. The number of daily cases recorded from October 2-12 stood below the 3,000-mark every day. On October 10 and September 29 as well, 48 fatalities were reported in the city, the highest number of deaths recorded in a day since July 16 when Delhi saw 58 fatalities. The 3,036 fresh cases on Tuesday were detected after 54,957 tests were conducted the previous day. Forty-five more fatalities have been recorded, taking the coronavirus death toll to 5,854, according to the latest bulletin issued by the Delhi health department. The tally of active cases on Tuesday rose to 21,490 from 20,535 the previous day. The total number of cases has climbed to 3,14,224, the bulletin added.